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KMID : 0361420140380050658
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Journal of Korean Academy of Rehabilitation Medicine
2014 Volume.38 No. 5 p.658 ~ p.664
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Reduction of Continuous Theta Burst Stimulation-Induced Motor Plasticity in Healthy Elderly With COMT Val158Met Polymorphism
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Lee Nam-Jae
Ahn Hyun-Jung
Jung Kwang-Ik
Ohn Suk-Hoon
Hong Jeong-Hoon
Kim Yun-Joong
Yoo Woo-Kyoung
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Abstract
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Objective: To delineate whether cortical plasticity induced by continuous theta burst stimulation (cTBS) differed according to catechol-O-methyltransferase (COMT) gene polymorphism in healthy older adults.
Methods: Eighteen healthy older volunteers (mean age 73.78±5.04; 12 females and 6 males) were recruited. Volunteers randomly assigned in either a sham-first or real cTBS first group participated in two separate TMS visits with at least a 2-day wash-out period. Genotyping was carried out at baseline by a separate researcher who was blinded. cTBS was delivered in a hot spot over M1 at an active motor threshold of 80%. Motor evoked potentials (MEPs) were obtained at 120% of the resting motor threshold before and after sham/cTBS.
Results: The relative MEP to baseline was significantly decreased 0 and 10 minutes post-stimulation and increased 40 minutes post-stimulation, as compared with the sham condition. Immediately after cTBS, the Val/Val group had a significantly reduced relative MEP value, as compared with the MET carrier group.
Conclusion: In healthy older persons, cTBS-induced motor plasticity was reduced in the COMT Val/Val group as compared with the 158Met carrier group.
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KEYWORD
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Transcranial Magnetic Stimulation, Catechol-O-methyltransferase, Neuronal plasticity, Genetic polymorphism, Motor cortex
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